Item no.
SAF-239824-10MG
Unit
1 x 10 mg
Molecular formula
C27H35FN2O4
Molecular weight
470,58
Shipment details
No Dangerous Good
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Description
A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of beta-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and beta-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in beta-arrestin2 is recruited to the active receptor.
Structure formula
Miscellaneous
Certificate of Analysis (specimen)
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Product data sheet
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