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CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2.

Item no.

SAF-239819-2MG

CAS Number

[473728-67-5]

Unit

1 x 2 mg

Molecular formula

C18H21N3O4

Molecular weight

343,38

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37C).

Structure formula

3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide

Analyte	CAS Number	Concentration	Unit	Additional information	Method
3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide	[473728-67-5]

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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