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Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Item no.

SAF-238811-5MG

CAS Number

[140651-18-9]

Unit

1 x 5 mg

Molecular formula

C9H10N6O

Molecular weight

218,22

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µ,M, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µ,M. Shown to exhibit antiproliferative activity in human tumor cell lines.

Structure formula

4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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