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Description

IKKgamma has been shown to play a critical role in NF-kappaB activation, as the regulatory subunit of IkappaB kinase, which phosphorylates inhibitors of NF-kappaB leading to their degradation. Upon cell stimulation, IKKgamma can be modified by Lys-63-linked or linear polyubiquitination, both of which are suggested to play key roles in cell signalling, including NF-kappaB activation. One of the E3 ligases responsible for Lys-63-linked IKKgamma polyubiquitination is TRAF6, which participates in several signalling pathways controlling immunity, skin development, osteoclast formation and brain functions.