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Bax Channel Blocker - CAS 335165-69-0 - Calbiochem A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties.

Item no.

SAF-196805-5MG

Unit

1 x 5 mg

Price on request

Description

A cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 microM) by inhibiting Bax channel activity., A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 microM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).

Structure formula

(+/-)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol

Analyte	CAS Number	Concentration	Unit	Additional information	Method
(+/-)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol	[335165-69-0]

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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