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Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem The Anaphase-Promoting Complex Inhibitor, TAME, also referenced under CAS 1784-03-8, controls the biological activity of Anaphase-Promoting Complex. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Item no.

SAF-172104-50MG

Unit

1 x 50 mg

Shipment details

No Dangerous Good

Price on request

Description

TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µ,M.

Structure formula

Nalpha-p-Tosyl-L-arginine methyl ester hydrochloride

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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