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Description

Full length, recombinant, human AMPK consisting of subunits alpha2/beta1/gamma1, each fused at the C-terminus to a His.Tag sequence and co-expressed in S. frugiperda insect cells using a baculovirus expression system. AMPK is involved in sensing energy levels in the cell that result from changes in AMP levels. AMPK is an upstream regulator of mTOR activation. The alpha-subunit contains a kinase domain, the beta-subunit contains a glycogen binding domain, and the gamma-subunit contains the regulatory AMP binding domain. The active complex is useful in the study of kinase activity regulation and inhibitor screening.