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Although the Chromolith(R) columns are well known for their robustness and longevity, guard columns are available to prolong the lifespan of Chromolith(R) analytical columns even further. These guard cartridges require a special holder.Chromolith(R) WP 300 RP-4, 5-4.6 guard cartridges are extremely easy to use. The guard cartridges are simply added directly in front of the main column to protect it from chemical or mechanical contamination. Due to the benefits of monolithic technology, and the convenience of Chromolith(R) guard columns, they are also popular for use with classical particulate columns. Moreover, guard columns can be used as trap columns when large sample volumes are to be injected. Guard columns should be changed frequently in order to avoid excessive accumulation of impurities.Chromolith(R) columns are made of monolithic silica with a characteristic bimodal pore structure. Chromolith(R) WP 300 RP-4, 5-4.6 guard cartridges are used with the Chromolith(R) Guard Cartridge Holder Bioinert 5 mm x 4.6 mm [1.52255]Learn more:Brochure: Race through your Separations on Any System. Chromolith(R) Monolithic Silica HPLC ColumnsAll Supelco HPLC Columns, including monolithic Chromolith(R) columns, are fully compatible to all HPLC and UHPLC Instruments.Supelco HPLC Products: The Best Choice for Any LC Instrument