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Description

The H1047R substitution in p110alpha is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation., Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110alpha containing the mutation H1047R alphaand untagged, recombinant, full length mouse p85alpha., Product Source: Coexpressed by baculovirus in Sf21 insect cells.