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Description

Complex of N-terminal 6His-tagged, recombinant, full-length human p110alpha containing the mutation E542K and untagged, recombinant, full-length human p85alpha., The E542K substitution is a somatic mutation in p110alpha that has been associated with tumours of the colon and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation.