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Description

Recombinant protein derived from the bioengineered human alpha1-antitrypsin gene fused to a His.Tag sequence and a FLAG-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). Extracellular application of alpha1-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays., Recombinant protein derived from the bioengineered human alpha1-antitrypsin gene fused to a His.Tag and a FLAG.Tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). alpha1-PDX can be used in extracellular applications to block the processing of furin substrates. alpha1-PDX has been shown to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.