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Description

A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µ,M, respectively, with 10 µ,M ATP, 10 µ,M luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µ,M against Promega's Kinase-Glo, ineffective against Kinase-Glo Plus and Kinase-Glo Max, at a 3-fold formulation dilution and 6.77 µ,M ATP)., A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µ,M, respectively, with 10 µ,M ATP, 10 µ,M luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µ,M against Promega's Kinase-Glo, ineffective against Kinase-Glo Plus and Kinase-Glo Max, at a 3-fold formulation dilution and 6.77 µ,M ATP).