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Description

A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARbeta and RARgamma over RARalpha (Kd = 34, 130, and 1100 nM, respectively, AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >>1 µ,M) or detectable activity toward RXRalpha (AC50 >1 µ,M). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo., A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARbeta and RARgamma over RARalpha (Kd = 34, 130, and 1100 nM, respectively, AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >>1 M) or detectable activity toward RXRalpha (AC50 >1 M). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin both in vitro and in vivo.