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Description

A cell-permeable and selective inhibitor of human Acetyl-CoA carboxylase 2 (ACC2) (IC50 = 2.8 µ,M), which does not inhibit human ACC1 at all at concentrations up to 100 µ,M, in vitro. It is also shown to inhibit the growth of yeast (IC50 = 3.8 µ,M), in which the native ACC1 gene is replaced with the human ACC2 strain, but not with the human ACC1 strain at concentrations <= 100 µ,M. This compound is not demonstrated to be toxic to human cells in culture at concentrations up to 10 µ,M.