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Category: Aromatics, Heterocycles, Protein Kinase Inhibitors and Activators, Sulfur and Selenium Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White Solid /// Application Notes: Vemurafenib selective BRAFV600E kinase inhibitor, an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. /// References: Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010)| Yang, H. et al.: Cancer Res., 70, 5518 (2010)| Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010)|