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Category: Carbohydrates and Derivatives, Heterocycles, Isotope Labelled Compounds, Nucleotides, Bases and Related Reagents /// Appearance: White Solid /// Application Notes: Isotope labelled beta-Pseudouridine is an isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called ? synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that beta-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes. /// References: Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003)| Hamma, T. et al.: Chem. Biol., 13, 1125 (2006)| Liang, X.H. et al.: RNA, 8, 237 (2002)| Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003)|