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Category: Aromatics, Miscellaneous Reagents /// Application Notes: 1,4-Dimethylnaphthalene is a polycyclic aromatic hydrocarbon (PAH) that has been found in dust particulate matter and is associated with activation of aryl hydrocarbon receptor as a major toxic mode of action in WB-F344 cell line. 1,4-Dimethylnaphthalene has been found to retard the development of epidermoid carcinomas in hamster buccal pouch. 1,4-Dimethylnaphthalene alters the genes associated with the maintenance of a G1/S phase block possibly through the induction of the cell cycle inhibitors KRP1 and KRP2 in potatoes. /// References: Malament, D.S., Shklar, G.: Carcinogenesis, 2, 723 (1981)| Campbell, M.A., et. al.: Fuct. Interg. Genomics, 12, 533 (2012)| Andrysik, Z., et. al.: Mutat. Res-Fund. Mol. M., 714, 53 (2011)