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Beschreibung

A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC = 0.2 and 4.5 microM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC >50 microM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.