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Beschreibung

A cell-permeable, water soluble, potent anti-tumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90alpha with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen)., A potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90alpha with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.

Strukturformel

17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride

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