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Beschreibung

Category: Chiral Reagents, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Pale Yellow Low Melting Solid /// Application Notes: The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis. /// References: Haussler, R., et al.: J. Biol. Chem., 247, 2328 (1972), Holick, M.F., Rec. Res. Canc. Res., 164, 3 (2003), Palmer, H.G., et al.: Cancer Res., 63, 7799 (2003), Welsh, J., et al.: J. Nutr., 133, 2425S (2003)