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Category: Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Pale Yellow Solid /// Application Notes: Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC). /// References: Bruns, C., et al.: Clin. Cancer Res., 6, 1936 (2000), Hennequin, L., et al.: J. Med. Chem., 45, 1300 (2002), Park, M., et al.: J. Biol. Chem., 278, 50624 (2003), Arao, T., et al.: Cancer Res., 64, 9101 (2004), Prueitt, R., et al.: Int. J. Cancer, 120, 796 (2007)