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Category: Aromatics /// Appearance: Liquid /// Application Notes: p-Toluoyl chloride is an aromatic compound used as a reagent to synthesize (+)-Yashabushitriol, a plant metabolite that is naturally found in the male flowers of Alnus sieboldiana matsum. p-Toluoyl chloride is also used as a reagent to prepare derivatives of Desloratadine (D290250). Desloratadine is a selective H1-receptor antagonist that has anti-inflammatory effects and is used to treat patients with allergic rhinitis. /// References: Berger, W.. et al.: Ann. All. Asth. Immun., 89, 485 (2002)| Fang, Z., et al.: Tetrahedron Lett., 54, 6834 (2013)| Feldman, K. & Simpson, R.: Tetrahedron Lett., 30, 6985 (1989)| Mu, S., et al.: Chin. Chem. Lett., 24, 531 (2013)