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Beschreibung

Category: Apoptosis, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White to Off-White Solid /// Application Notes: A widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels. /// References: Treiman, M. et al.: Trends Pharmacol. Sci., 19, 131 (1998)| Korge, P. et al.: Eur. J. Biochem., 265, 273 (1999)| Tsukamoto, A. Cell Biol. Int., 17, 969 (1993)| Kutinova C.N. et al.: Cell Biol. Toxicol., 23, 337 (2007)|