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Beschreibung

Category: Amines, Aromatics, Chiral Reagents, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: L-Propoxyphene-d5 Hydrochloride is the isotope labelled analog and L-isomer of Propoxyphene Hydrochloride (P831500), a controlled substance (opiate) and analgesic (narcotic). The alpha-DL-and D-diastereoisomers possess marked analgesic activity in contrast to the beta-diastereoisomers which are substantially inactive. Oral administration of L-Propoxyphene Hydrochloride enhances the analgesic activity of D-Propoxyphene Hydrochloride. /// References: Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971)| McEwan, B., et al.: Anal. Profiles Drug Subs., 1, 301 (1972)| Murphy, P.J., et al.: J. Pharmacol. Exp. Ther., 199, 415 (1976)