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Category: Aromatics /// Application Notes: Phenyl chloroformate is a corrosive liquid that is used to synthesize Urazole, a five membered heterocyclic compound that reacts with aldoses to form alpha and beta pyranosides and furanosides. Phenyl chloroformate is also used as a reagent to prepare Sorafenib (S676850), a multikinase inhibitor that targets the tumour and tumour vasculature in patients with melanoma. /// References: Boettecher, B. & Meister, A.: Anal. Biochem., 138, 449 (1984)| Chai, W., et al.: Tetrahedron Lett., 53, 3514 (20112)| Eisen, T., et al.: Brit. J. Cancer, 95, 581 (2006)| Kolb, V., et al.: J. Mol. Evol., 38, 549 (1994)| Llovet, J., et al.: Engl. J. Med., 359, 378 (2008)