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Beschreibung

Category: Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Metabolites and Impurities, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: Orange to Red Solid /// Application Notes: Nitrocefin is a chromogenic beta-lactamase substrate that undergoes colour change from yellow to red as the amide bond in the beta-Lactam ring is hydrolyzed by beta-lactamase. Nitrocefin undergoes colour changes induced by lactamases produced by Gram-positive and Gram-negative bacteria. Several studies have utilized the colour changing properties of Nitrocefin for the detection of beta-lactamase activity from bacterial cell extracts by isoelectric focusing and spectroscopy. Nitrocefin has also been used in studies involving beta-lactamase resistant antibiotics. /// References: Yang, H., et al.: Biochem., 51, 3839 (2012)| El, Z., et al.: J. Pure. Applied. Microbiol, 5, 511 (2011)| Nguyen, H.M., et al.: J. Chem. Info. Modeling., 51, 3226 (2011)|