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Category: Aromatics, Amines, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: Yellow Solid /// Application Notes: Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-alpha-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction. /// References: Foresti, R., et al: J. Biol. Chem., 272, 18411 (1997)| Cardenas, A., et al.: J. Neurochem., 74, 2041 (2000)| Degterev, et al.: Nat. Chem. Biol., 1, 112 (2005)| Hitomi, J., et al.: Cell, 135, 1311 (2008)|