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Category: Aromatics, Carbohydrates and Derivatives, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Yellow Solid /// Application Notes: Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Mithramycin A inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells. /// References: Miller, et al.: Am. J. Med. Sci., 294, 388 (1987), Demicheli, et al.: Biochem. Biophys. Res. Commun., 177 511 (1991), Max, H., et al.: Cancer Res., 63, 7436 (2003), Lockman, J., et al.: J. Med. Chem., 53, 8734 (2010)