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Category: Amines, Aromatics, Mutagenesis Research Chemicals, Nicotine Derivatives /// Appearance: Pale Orange to Pale Red Gel /// Application Notes: (S)-4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol is the S-enantiomer of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which is a major metabolite of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (M325750). It is a tobacco specific N-nitrosamine (TSNA) and a potent pulmonary carcinogen. The R-enantiomer of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, (R)-NNAL, tends to be significantly more tumorigenic than the S-entiomer, (S)-NNAL. /// References: Yang, Y.Y., et al.: J. Chromatogr. A, 1218, 6505 (2011)| Carmella, S.G., et al.: J. Cancer Res., 53, 721 (1993)| Upadhyaya, P., et al.: Carcinogenesis, 20, 1577 (1999)