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Category: Carbohydrates and Derivatives, Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Pale Beige Solid /// Application Notes: 12-O-Methyl Clarithromycin (Clarithromycin EP Impurity F) is a methylated impurity of the semi-synthetic macrolide antibiotic Clarithromycin (C559750). 12-O-Methyl Clarithromycin was shown to inhibit uptake of Clarithromycin into the lung cells. /// References: Chen, X. et al.: Zhong. Yao., 17, 32 (2008)| Yoshida, H. et al.: Jap. J. Antibiot., 53, 615 (2000)| Omura, S. et al.: Yakug. Zas., 112, 593 (1992)|