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Category: Miscellaneous Reagents /// Appearance: White Solid /// Application Notes: L-Menthyl 2,2-Dihydroxyacetate is used as a reagent in the synthesis of Lamivudine (L172500), a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics. /// References: Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944)| Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997)| Perry, C.M., et al.: Drugs, 53, 657 (1977)| Goodyear, M.D., et al.: Tetrahedron Lett., 46, 8535 (2005)| Kametani, T., et al.: Heterocycles, 25, 241 (1987)