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Category: Apoptosis, Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: Off-White Solid /// Application Notes: Labelled MDV 3100. MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer. /// References: Scher, H.I. et al.: Lancet, 375, 1437 (2010)| Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010)| Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011)|