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Beschreibung

Application Notes: 3-(4-Maleimidoacetamido)propyl-25-Hydroxy-Vitamin D3 is a derivative of Vitamin D3, the vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. It occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. It modulates the proliferation and differentiation of both normal and cancer cells. It also has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. /// References: Haussler, R., et al.: J. Biol. Chem., 247, 2328 (1972)| Holick, M.F., Rec. Res. Canc. Res., 164, 3 (2003)| Palmer, H.G., et al.: Cancer Res., 63, 7799 (2003)| Welsh, J., et al.: J. Nutr., 133, 2425S (2003)