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Beschreibung

Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Tyrosine Kinase Inhibitors /// Appearance: Pale Yellow to Light Yellow Solid /// Application Notes: Linsitinib is a small-molecule dual insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor. IGF-I receptor (IGF-IR) has been implicated in the promotion of tumorigenesis, metastasis and resistance to cancer therapies and thus Linsitinib may be a useful anticancer agent. /// References: Mulvihill, M.M.J. et al.: Fut. Med. Chem., 1, 1153 (2009)| Flanigan, S.A. et al.: Clin. Cancer Res., 16, 5436 (2010)| McKinley, E.T. et al.: Clin. Cancer Res., 17, 3332 (2011)|