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Category: Apoptosis, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Pale Yellow to Yellowish Beige Solid /// Application Notes: KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro /// References: Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009)| Gaymes, T.J. et al.: Haematologica, 94, 638 (2009)|