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Category: Aromatics, Metabolites and Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Clear Colourless Oil /// Application Notes: (±)-Ibuprofen Methyl Ester is a phototoxic, photoproduct of Ibuprofen (I140000), a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Ibuprofen is also used as an anti-inflammatory drug. /// References: Miranda, M.A., et. al.: Toxicol. In Vitro, 5, 451 (1991)| Busson, M., et al.: J. Int. Med Res., 14, 53 (1986)| Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993)| Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)