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Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White Solid /// Application Notes: I-BET 151 is part of a novel series of quinoline isoxazole BET family bromodomain inhibitors, a family of four proteins that selectively bind to aceylated lysine residues in histone. I-BET 151 play key roles in many cellular processes, including anti-inflammatory gene expression, mitosis, and viral/host interaction by controlling the conformation of histone acetylation -dependent chromatin complexes. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential anti-inflammatory activities upon administration. /// References: Seal, J., et al.L Bioorg. Medn. Chem. Letters., 22, 2968 (2012)| Mirguet, O., et al.: Bioorg. Medn. Chem. Letters, 22, 2963 (2012)| Dawson, M.A., et al.: Nature., 478, 529 (2011)|