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Category: Amines, Aromatics, Metabolites and Impurities /// Application Notes: 3'-Hydroxy-4'-methoxydiclofenac is a derivative of Diclofenac (Sodium Salt: D436450). Diclofenac is the first non-steroidal anti-inflammatory drug (NSAID) that is derived from phenylacetic acid. Diclofenac, like other NSAIDs, primarily works by targeting the cyclo-oxygenase pathway in the arachidonic acid cascade, reducing the formation of inflammation mediators in the body. /// References: Ku, E., et al.: Am. J. Med., 80, 18 (1986)| Simmons, D., et al.: Proc. Nat. Acad. Sci., 96, 3275 (1999)| Small, R.: Clin. Pharm., 8, 545 (1989)