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Category: Amino Acids and Derivatives, Aromatics, Neurochemicals, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Grey to Brown Solid /// Application Notes: 6-Hydroxy-L-DOPA (Levodopa EP Impurity A) is the 6-hydroxy derivative of the amino acid L-DOPA (D533751) with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase. /// References: Jaim-Etcheverry, G. et al.: Brain Res., 100, 699 (1975)| Kostrzewa, R.M. et al.: Amino Acids, 14, 175 (1998)| Berthet, A. et al.: J. Neurosci., 29, 4829 (2009)|