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Category: Metabolites and Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Beige Solid /// Application Notes: (R,R)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway. /// References: Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005)| Drahl, C. et al.: Chem. and Eng. News, 87, 41 (2009)