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Beschreibung

Category: Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds, /// Appearance: White to Pale Yellow Solid /// Application Notes: An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARdelta agonist. Exhibits selectivity for PPARdelta compared to PPARalpha and PPARgamma. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training. /// References: Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003)| Chem. and Eng. News, p. 9, May 8, 2017