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Application Notes: 5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro beta-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3. /// References: Richter, J., et al.: J. Am. Chem. Soc., 129, 12857 (2007)| Yeung, B., et al.: J. Med. Chem., 53, 5155 (2010)|