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Category: Aliphatics, Metabolites and Impruities, Isotope Labelled Compounds,Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Light Pink Solid /// Application Notes: Fumaric Acid Monomethyl Ester-d5 is the isotope labelled analog of Fumaric Acid Monomethyl Ester. Fumaric acid monomethyl ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Fumaric acid monomethyl ester is potent nicotinic acid receptor agonist. Fumaric acid monomethyl ester has also been shown to selectively stimulate of T helper 2 cytokine response. It is also the active metabolite of Dimethyl Fumarate (D464965), a compound that is used as a treatment for the relapsing forms of multiple sclerosis and psoriasis. /// References: de Jong, R. et al.: Eur. J. Immunol., 26, 2067 (1996)| Litjens, N.H.R. et al.: Br. J. Dermatol., 154, 211 (2006)| Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006)| Tang, H. et al.: Biochem. Biophys. Res. Comm., 375, 562 (2008)