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Beschreibung

Category: Chiral Reagents, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White Solid /// Application Notes: 28-Epirapamycin is an epimer of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa'Nui. Used as an immunosuppressant, antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation, it is especially useful in kidney transplants. /// References: Yang, W., et. al.: Org. Lett., 1, 2033 (1999)| Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977)| Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993)| Kahan, B.D., et al.: Lancet, 356, 194 (2000)| Holmes, D.R., et al.: Circulation, 109, 634 (2004)