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Beschreibung

Category: Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: White to Off-White Solid /// Application Notes: Labelled Dipyrone. Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models. /// References: Reith, J. et al.: Lancet, 347, 422 (1996)| Grau, A. et al.: J. Neurol. Sci., 171, 115 (1999)| Schwarz, S. et al.: Neurology, 2000, 54, 354 (2000)| Greer, D. et al.: Stroke, 39, 3029 (2008)|