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Appearance: Pale Yellow Solid /// Application Notes: (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol is proven to have amphetamine-like effects and is being used for recreational drug use. It is one of a new class of synthetic stimulants known as pipradol derivatives. It inibits neurite growth in PC12 cells which contributes to its neurotoxic effects. It is used as a reagent in the synthesis of (S)-duloxetine which is an antidepressant drug. It is used to prepare chiral Corey-Bakshi-Shibata catalyst which is used in organic synthesis. /// References: Coppola, M., et al.: Toxicol. Lett., 212, 57 (2012)| Lee, S., et al.: B. Kor. Chem. Soc., 35, 1894 (2014)| Kaizaki, A., J. Toxicol. Sci., 35, 375 (2010)| Corey, E., et al.: J. Am Chem. Soc., 109, 5551 (1987)|