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Category: Amines, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-phenylalaninamide is an intermediate in the synthesis of gamma-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid beta-peptide (Abeta), the major causative agent in Alzheimer disease (AD). /// References: Fearon, K., et al.: J. Med. Chem., 30, 1617 (1987)|