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Category: Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: N-[(2R,4R,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide is an intermediate in the synthesis of gamma-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid beta-peptide (Abeta), the major causative agent in Alzheimer disease (AD). /// References: Dias, L.C., et al.: Synthesis., 4, 603 (2003)| Nadin, A., et al.: Tetrahedron., 57, 1861 (2001)|