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Appearance: White Solid /// Application Notes: Labelled Dimethyl Fumarate (D464965). Dimethyl Fumarate is the methyl ester form of Fumaric Acid (F500380), and is a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis. Dimethyl Fumarate is effective in treating multiple sclerosis by mediating the activation of the nuclear 1 factor (Nrf2) antioxidant response pathway, resulting in neuroprotective effects. Dimethyl Fumarate is also used in cycloaddition reactions involving ylides, benzenes and amino acids. /// References: Albrecht, P., et al.: J. Neuroinflammation, 9, 2094 (2012)| Chen, X. et al.: J. Am. Chem. Soc., 130, 5652 (2008)| Gold, R., et al.: New Engl. J Med., 367, 1098 (2012)| Gothelf, A. et al.: Angew. Chem., Int. Ed., 41, 4236 (2002)| Schmidt, T., et al.: Bioorg. Med. Chem., 15, 333 (2007)