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Appearance: White Solid /// Application Notes: (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid 2,5-Dioxo-1-pyrrolidinyl Ester is an intermediate in the synthesis of ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone (P309025). ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence. /// References: Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002)| Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004)| Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004)| Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005)| Habb, F., et al.: Eur. Urol. 47, 376 (2005)| Payne, C.K., et al.: Drugs, 66, 175 (2006)